After the Kids Leave: Why Your Joy Needs a Different Formula
- Michelle Shyam

- Dec 29, 2025
- 6 min read
If you’re in your late 40s, facing the early empty-nest phase with older college-going kids, you might be experiencing a mix of emotions, including sadness and a sense of loss. It’s a significant transition, but there are ways to enhance your well-being and find joy in this new chapter. This post will explore four key hormones—dopamine, serotonin, endorphins, and oxytocin—that can help boost your mood and happiness.

Here’s a breakdown of the differences between these hormones and examples of activities that stimulate them:
Dopamine - The Reward Hormone
Dopamine is associated with the brain's reward system. It plays a crucial role in motivation, pleasure, and reinforcement learning. When you achieve a goal or experience something pleasurable, dopamine levels rise, creating feelings of satisfaction and happiness.
Triggers:
Achieving Goals: Completing tasks or setting and reaching small goals.
Physical Exercise: Particularly activities you enjoy.
Learning New Skills: Engaging in new hobbies or educational activities.
Listening to Music: Especially music you love.
Creative Activities: Painting, writing, or any form of artistic expression.
Serotonin - The Feel-Good Hormone
Serotonin helps regulate mood, sleep, appetite, and digestion. It contributes to feelings of well-being and happiness. Low levels of serotonin are linked to depression and anxiety.
Triggers:
Sunlight Exposure: Spending time outdoors in natural light.
Exercise: Activities like walking, jogging, or yoga.
Healthy Diet: Foods rich in tryptophan, such as turkey, nuts, and eggs.
Meditation and Mindfulness: Practices that focus on relaxation and stress reduction.
Positive Thinking: Gratitude exercises and focusing on positive experiences.
Endorphins - The Natural Painkillers
Endorphins are released in response to pain or stress and help alleviate discomfort. They create a sense of well-being and euphoria, often described as a "runner’s high."
Triggers:
Exercise: Particularly aerobic exercises like running, swimming, or biking.
Laughter: Watching comedies or spending time with funny friends.
Dark Chocolate: Eating a small amount of dark chocolate.
Spicy Foods: Consuming spicy foods.
Creative Arts: Engaging in activities like painting, music, or crafting.
Oxytocin - The Love Hormone
Oxytocin is associated with social bonding, trust, and intimacy. It promotes feelings of love and connection and reduces stress.
Triggers:
Physical Touch: Hugs, cuddles, sex and holding hands.
Quality Time with Loved Ones: Sharing meals and engaging in meaningful conversations.
Pet Interaction: Playing with or petting animals.
Volunteer Work: Helping others and community service.
Expressing Affection: Giving compliments and expressing love and appreciation.
How To Stay Happy...
To determine which activities trigger each hormone, consider the primary function and typical responses associated with each hormone. Consistently engaging in these activities on a daily basis will make you a happier and healthier person.
Dopamine: Look for activities that provide a sense of accomplishment, reward, or pleasure. These are often activities where you set goals, achieve something, or experience enjoyment and creativity.
Serotonin: Focus on activities that improve mood stability, relaxation, and well-being. These activities are often related to physical health, mental tranquility, and environmental exposure.
Endorphins: Engage in activities that involve physical exertion, pain relief, or stress reduction. These are usually physical exercises, laughter-inducing actions, or sensory pleasures like certain foods.
Oxytocin: Seek out activities that involve social interactions, trust, and bonding. These include physical touch, social engagements, and activities that foster emotional connections.
Boost Dopamine

Engaging in activities as a couple can be a wonderful way to boost dopamine levels while also strengthening relationships. The key word is "Goal". Set your #couplesgoals for each day of the week so that you look forward to engaging in an activity together that you both enjoy. Feel free to create your own weekly schedule.
Setting goals and working on them each day can significantly enhance our happiness and well-being. This practice taps into the powerful effects of dopamine. When you set a goal and make progress towards it, your brain releases dopamine, creating feelings of satisfaction and motivation. This not only makes you feel good in the moment but also encourages you to keep moving forward.
Why Daily Goals Make Us Happy?

Sense of Accomplishment: Completing even small tasks each day provides a sense of achievement, boosting your confidence and mood.
Motivation: The anticipation of achieving your goals and the subsequent dopamine release keep you motivated and engaged.
Structure and Purpose: Having daily goals gives your day structure and a sense of purpose, which can be particularly beneficial during transitions like the empty nest phase.
Progress and Growth: Working on goals each day leads to personal growth and development, providing long-term satisfaction and happiness.
Incorporating individual goal-setting into your daily routine can create a positive cycle of achievement and reward. This not only enhances your day-to-day happiness but also helps you navigate life’s transitions with a sense of purpose and fulfillment.
Boost Serotonin
Serotonin is a crucial neurotransmitter in the brain that significantly influences our mood, emotions, and overall sense of well-being. Often referred to as the "feel-good hormone," serotonin helps regulate mood, social behavior, appetite, digestion, sleep, memory, and sexual desire. For early empty nesters, understanding and boosting serotonin can be particularly helpful in dealing with the sadness and emotional adjustments of this phase.

Mood Enhancement
Serotonin plays a vital role in stabilizing mood. Adequate levels of serotonin are associated with feelings of happiness, calmness, and emotional stability. When serotonin levels are optimal, you typically experience a balanced and positive mood. For empty nesters, activities that promote serotonin production can help counteract feelings of loneliness and loss.
Impact on Depression and Anxiety
Low levels of serotonin have been linked to mood disorders such as depression and anxiety. Insufficient serotonin can lead to feelings of sadness, irritability, and anxiety. This is why many antidepressant medications, such as selective serotonin reuptake inhibitors (SSRIs), aim to increase serotonin levels in the brain to improve mood and alleviate depressive symptoms. Early empty nesters experiencing increased anxiety or sadness may benefit from natural serotonin-boosting activities to improve their emotional well-being.
Stress Reduction
It helps mitigate the effects of stress. It promotes relaxation and a sense of well-being, making it easier to cope with the stressors of adjusting to an empty nest. Activities that boost serotonin, such as exercise, sunlight exposure, and mindfulness practices, can help reduce stress levels and improve emotional resilience during this transitional period.
Improved Sleep
Serotonin is a precursor to melatonin, the hormone that regulates sleep-wake cycles. Adequate serotonin levels help ensure a healthy sleep pattern, which is crucial for mood regulation. Poor sleep can lead to irritability and mood swings, while good sleep supports emotional stability. Ensuring good sleep hygiene can be especially important for empty nesters adapting to a quieter home environment.
Overall Well-Being
Beyond mood, serotonin contributes to overall well-being by influencing various bodily functions. For example, it helps regulate appetite and digestion, which can impact energy levels and mood. A healthy balance of serotonin supports a well-rounded sense of physical and mental health. Engaging in enjoyable and fulfilling activities can help early empty nesters find new routines and purposes, supporting their overall well-being.
Boosting serotonin on a daily basis can help improve mood, reduce stress, and enhance overall well-being. In the infographic below are seven very specific ways you can boost serotonin each day.
On the other hand, certain habits and activities can negatively impact serotonin levels, leading to decreased mood and overall well-being. Here are some common activities that might be lowering or wasting your serotonin:

Lack of Sunlight Exposure
Insufficient exposure to natural light can reduce serotonin production, leading to feelings of sadness and lethargy.
Sedentary Lifestyle
Sitting for prolonged periods without engaging in regular physical exercise.
Poor Diet
Diets low in tryptophan (an amino acid necessary for serotonin production) and high in processed foods can negatively affect serotonin levels.
Chronic Stress
Long-term stress can deplete serotonin levels and disrupt the balance of other neurotransmitters.
Poor Sleep Habits
Inconsistent sleep schedule, staying up late, or experiencing frequent interruptions during the night.
Excessive Alcohol Consumption
Alcohol can temporarily boost serotonin, but chronic use can lead to overall lower levels and depressive symptoms.
Negative Thought Patterns
Engaging in frequent negative self-talk, pessimism, or dwelling on past mistakes.
Isolation
Spending long periods alone without connecting with friends or family.
High Sugar Intake
High sugar consumption can cause blood sugar spikes and crashes, negatively affecting mood and serotonin levels.
Overuse of Technology
Spending hours on smartphones, computers, or watching TV, particularly in the evening.
For empty nesters, dopamine may push you to fill the sudden quiet with constant doing, while serotonin invites you to settle into meaning and contentment. This phase isn’t about replacing what’s gone—it’s about learning to feel whole again in a new way.



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